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KMID : 1100220060050020048
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Dementia and Neurocognitive Disorders
2006 Volume.5 No. 2 p.48 ~ p.55
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ECD-SPECT Findings of Semantic Dementia and Frontotemporal Dementia: Visual and Statistical Parametric Mapping Analysis
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Cho Hyun
Yang Dong-Won
Kim Beum-Saeng
Shon Young-Min
Shim Young-Soo
Chung Yong-An
Sohn Hyung-Sun
Juh Ra-Hyeong
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Abstract
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Background: Semantic dementia (SD) and frontotemporal dementia (FTD) are two major variants of frontotemporal lobar degeneration (FTLD) which have unique clinical manifestations. We studied to determine the patterns of regional cerebral blood flow (rCBF) in SD and FTD.
Methods: We observed characteristic patterns of rCBF in SD and FTD with statistical parametric mapping (SPM) analysis of 99mTc-ECD single photon emission computed tomography (SPECT). Five patients with SD and 5 patients with FTD as well as 12 age-matched normal controls underwent brain MRI and ECD-SPECT scan. We conducted an SPM analysis to identify brain regions with hypoperfusion in each of groups.
Results: Visually, ECD-SPECT images of the SD patients showed decreased rCBF in bilateral anterior temporal lobes, more severe on the left and those of the FTD patients did in bilateral prefrontal and anterior cinglulate gyrus. SD group had more perfusion defect in the left temporal area than FTD group. FTD group showed more perfusion defect in the medial frontal, right prefrontal and anterior cingulate areas than SD group.
Conclusions: In clinical syndromes of SD and FTD, two different patterns of rCBF were identified. SD and FTD are distinctive degenerative dementias with different cortical involvement which can be differentiated by ECD-SPECT study.
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KEYWORD
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Semantic dementia, Frontotemporal dementia, Single photon emission computed tomography, Statistical parametric mapping
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